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PROGENEX Force Research

The Science of PROGENEX Force

One serve, 15 minutes before your workout and you’ll feel the power surge within, enabling you to take your training and performance to the highest level and achieve incredible results both in and outside the gym. 


The Force is in You!

PROGENEX Force contains a special proprietary blend of ingredients that is specifically formulated to maximize your body’s ability to train harder, longer so that you can realize superior results.


Surge NOS Activator™

PROGENEX Force contains Surge NOS Activator™–a proprietary whey peptide that enhances nitric oxide production in endothelial cells. This process is crucial for vasorelaxation, or greater arterial dilation (Cosentino, 1995)(Bryan, 2009).

Vasodilation means you’ll experience:

  • Increased blood flow and oxygen transport
  • Maximized and prolonged VO2 Max
  • Reduction in blood pressure, and
  • Rapid delivery of key nutrients during training

How does Surge NOS Activator ™ work? Surge NOS Activator™ is an isolated concentration of key whey peptides that enhance nitric oxide production in endothelial cells. Unlike some NO products, the mechanism of action in Surge NOS Activator™ is different in that we don’t simply just add more amino fuel, such as arginine, to support NOS activity. Surge NOS Activator™   actually switches on the enzymatic pathway to utilize your own amino acids to start the NOS response.

If you are unfamiliar with the NOS response or even the “radical” molecule known as nitric oxide, allow me to explain. Known as NOS, nitric oxide is an important cellular signalling molecule. It is often referred to as the endothelium-derived relaxing factor—EDRF—because the endothelium (inner lining) of blood vessels uses nitric oxide to signal the surrounding smooth muscle to relax. This relaxation is referred to as vasorelaxation, and/or vasodilation. It is this increased arterial dilation that allows for greater blood flow.

It was Ferid Murad and his colleagues who first made this important discovery back in 1973. The implications for modern day medicine were so far-reaching and profound that in 1992, nitric oxide was named “Molecule of the Year,” and six years later, Murad and his colleagues were awarded the Nobel Prize in Physiology. Their landmark research spurred pharmaceutical companies to create medicines with the ability to successfully treat angina, atherosclerosis, diabetes, hypertension, and/or erectile dysfunction (yes, Viagra also harnesses the power of nitric oxide).

It didn’t take long for athletes and sports nutritionists to also realize the significance of Murad’s discovery. Supplements harnessing the power of nitric oxide abound, but only PROGENEX Force contains the patent-pending technology and proprietary dosing that specifically isolates and concentrates key whey peptides responsible for activating the production of nitric oxide in endothelial cells, resulting in vasorelaxation.

Just one serving of PROGENEX Force and you will feel the power Surge, enabling you to experience increased blood flow, increased oxygen transport and extended VO2 max. You’ll also feel your muscles fuel up as two ingredients course rapidly through your expanded arterial walls, delivering strict muscle fuel before, during, and after your gruelling workout.*


Surge Delivers the Force!

Increased blood flow and oxygen transport are awesome, indeed, but PROGENEX Force sports nutritional supplement doesn’t stop there. Our Surge NOS Activator ™ ensures the rapid delivery of key nutrients during training. The two key nutrients included in PROGENEX Force are:  Creatine Monohydrate  and 2:1:1 BCAA’s (Branched Chain Amino Acids). Both are incredible sources of strict muscle fuel that have been scientifically proven to enhance athletic performance.


Creatine is a substance naturally produced in your body. It can also be obtained from consuming meat and/or through supplementation. Creatine plays a vital role in providing energy to your cells (particularly your muscles) by fuelling the creation of ATP.

Because of the important role creatine plays in fuelling the production of ATP, individuals with higher creatine concentrations in their body tend to exhibit greater strength, bursts of speed, greater muscle mass, and increased protein synthesis (muscle building and repair).

Knowing the above, it’s easy to understand why creatine has become one of the most popular sports supplements on the market, as well as the most researched. In fact, studies on creatine have consistently demonstrated its ability to:

  • Increase muscular strength, power and body mass (Okudan, 2005), (Earnest, 1995), (Volek, 1999)
  • Reduce muscle fatigue in anaerobic exercise (Hoffman, 2005)
  • Enhance protein synthesis (Ingwall, 1974)

    There are numerous studies demonstrating the benefits of creatine supplementation. I only cited a few, but if you’d like to learn more simply Google “creatine and enhanced athletic performance.”



    2:1:1 BCAA’s

    Along with creatine, PROGENEX Force sports nutritional supplement delivers leucine, isoleucine and valine. These branched chain amino acids (BCAA’s) are crucial for muscle growth, repair and recovery. But that is not all, leucine, isoleucine and valine are the primary amino acids oxidized during intense exercise (Blomstrand, 2006). That is why it is extremely helpful to supplement with BCAA’s prior to working out. Supplementing with BCAA’s pre-workout supplies your muscles with high octane fuel during your workout, as well as increases protein synthesis, decreases catabolization (muscle breakdown) and enhances post-workout recovery (Candeloro, 1995), (Shimomura, 2004), (Matsumoto, 2007)

    For this reason, you’ll find BCAA’s in pretty much any decent pre- and post-workout product. However, what really sets the PROGENEX Force sports nutritional supplement formula apart from the competition is our 2:1:1 BCAA ratio.  Leucine is the most important BCAA when it comes to muscle growth and repair. That is precisely why we add more leucine. The 2:1:1 ratio is optimal for helping your muscles maintain an anabolic state  both during and after your workouts , as well as optimizing strength gains (Coburn, 2006).

    Another advantage with our special BCAA formulation is its peptide form. Proteins in peptide form have superior absorption rates, protein efficiency ratios, and have been shown to enhance and speed recovery much more effectively than proteins in amino acid form (Boza, 2000), (Poullain, 1989). Consequently, BCAAs in peptide form are more potent and powerful than BCAAs in amino acid form (Markus, 2008). And that, coupled with our precise dosing, is what makes our 2:1:1 BCAAs such an incredible addition to PROGENEX Force sports nutritional supplement and sets us apart from any other product.


    Fuelling your muscles is an important component to any pre-workout supplement, but strict muscle fuel without added buffering agents to fight against fatigue would make for a weak pre-workout drink. That is why PROGENEX Force sports nutritional supplement contains Citrulline and Beta-Alanine.


    Citrulline is a non-essential amino acid produced naturally in the body and also found in foods such as melons. It has gained widespread recognition in the sports nutrition field because of the role it plays in facilitating the elimination of ammonia. Because ammonia accumulation in the blood and tissues has been shown to block cellular energetic processes (Lowenstein, 1972), (Bryla, 1979), buffering against its production and facilitating its elimination through citrulline supplementation is of utmost importance for individual’s seeking to achieve optimal athletic performance.

    Citrulline’s anti-fatiguing properties (Janeira, 1998)* were reason enough to include it in our list of PROGENEX Force ingredients, but impressively enough.

    Citrulline has also been shown to:

    • Increase Nitric Oxide Production (because citrulline can increase arginine levels, which in turns produces nitric oxide)
    • Increase ATP (energy) (Bendahan, 2002)
    • Enhance Anaerobic Performance and Reduce Post-Exercise Muscle Soreness (Perez-Guisado, 2010)

      *Citrulline malate effects on the aerobic-anaerobic threshold recovery and in post-exercise blood lactate recovery Janeira, M. A.; Maia, J. R.; Santos, P. J. Medicine & Science in Sports & Exercise. 30(5) (Supplement):155, May 1998.


      Like citrulline, beta-alanine is a non-essential amino acid that can increase the level of carnosine in the muscle. As a precursor to carnosine, beta-alanine joins with the amino acid histidine through a peptide bond to form carnosine in the muscle.  Muscle carnosine is the major buffering agent, or neutralizer, of hydronium ions that lead to muscle fatigue and failure.

      The benefits of beta-alanine have been researched in several different studies with remarkable results.

      Beta-alanine can:

      • Increase muscle carnosine for prolonged periods (Baguet, 2009)
      • Increase muscle buffering capacity (Derave, 2007)
      • Decrease acidosis (Stout, 2006)
      • Improve endurance (Van Thienen, 2009)
      • Delay fatigue (Derave, 2007)
      • Increase strength (Hill, 2007) (Hoffman, 2006)
      • Speed recovery from intense exercise (Stout, 2006)

        Together, beta-alanine and citrulline will keep fatigue at bay, allowing for enhanced endurance and increased working capacity.

        Low-Dose Caffeine

        Some pre-workout drinks contain high doses of caffeine, but PROGENEX Force sports nutritional supplement uses only 100 mg. This low dose is the optimal addition for promoting high energy levels while increasing mental clarity and focus.

        Caffeine supplementation has also been shown to enhance athletic endurance and fat oxidation (Costill, 1978), as well as decrease muscle glycogenolysis—resulting in prolonged time to exhaustion (Spriet, 1992).


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